DNAnexus

POPULATION GENOMICS SOLUTION BRIEF A Blueprint for Scaling Population

A Blueprint for Scaling Population Genomics to Advance Precision Health

OVERVIEW

Population health has become a strategic imperative for health systems, which are launching genomics programs to improve patient outcomes, accelerate research, and ensure financial vitality. By combining genomic and clinical data at scale, these initiatives create powerful "living laboratories." The value of large-scale human genetic data is now understood to be a critical asset for biological discovery and improved health management.

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The Core Challenge: Data Integration at Scale The rise of population genomics has revealed a myriad of new ways for health

The rise of population genomics has revealed a myriad of new ways for health systems to advance discovery, patient outcomes, and clinical operations. Population genomics is a multidisciplinary endeavor, requiring clinical, technical, scientific, operational, and informatics expertise in equal parts. Standing up and scaling population health programs requires overcoming significant hurdles, any of which can imperil the massive investment in time and organizational resources required for success.

Too often, health systems find that the informatics infrastructure used to support the data requires uncomfortable design tradeoffs: security vs. access, cost vs. scale, usability vs. governance. Overly simplistic or general IT solutions lack the built-forpurpose features and functionality that enable return on investment for all stakeholders. At scale, these programs and their resulting datasets can become overly constrained, turning what should be a crown jewel data asset that supports insights, discovery, and quality in patient care into an expensive and narrow resource available only to a subset of users. The Solution: A Unified, Cloud-Based Platform

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The Solution: A Unified, Cloud-Based Platform Leading initiatives like the UK Biobank and Geisinger MyCode demonstrate that a

Leading initiatives like the UK Biobank and Geisinger MyCode demonstrate that a unified, cloud-native platform is the foundational solution. This approach breaks down data silos by creating a single, integrated data asset, which enables dynamic querying, analysis, and collaboration. By centralizing data, researchers are brought to the data, which eliminates risky large-scale transfers and ensures everyone works on the same curated datasets.

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Five Core Lessons from Pioneering Programs

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Population Genomics | Solutions Brief

The DNAnexus Platform Solution

From Siloed Data to Integrated Discovery: A Unified Platform for Population Health

Figure 1: DNAnexus unified data platform

Unified Data Integration: Combines genomic, clinical, and other data into a single source of truth with an intuitive cohort browser.

Scalable Analytics: Provides high-throughput, on-demand compute for complex analyses, supporting major workflow languages and AI/ML tools.

This model lowers the cost of entry by shifting from prohibitive upfront capital expenditures to a scalable operating expense. By leveraging a proven platform like DNAnexus, health systems can reduce operational costs, accelerate discovery, and build a sustainable program that integrates genomic insights into everyday healthcare.

Cloud platforms like DNAnexus have made launching a population-scale genomics program a financially viable goal.

Ready to learn more? Contact us today to schedule a platform demo: DNAnexus.com/contact

Robust Security and Compliance: Built with industry-leading security, including end-to-end encryption, fine-grained access controls, and complete audit trails to meet standards like HIPAA and GDPR.